ABSTRACT
<p><b>Objective</b>Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually. Nevertheless, controversies exist for the grouping of ABC method and the intervals of gastroscopy surveillance for each group. In this review, we summarized these popular concerned topics for providing useful references to the healthcare practitioner in clinical practice.</p><p><b>Data Sources</b>The PubMed databases were systematically searched from the inception dates to November 22, 2017, using the keywords "Helicobacter pylori," "Pepsinogens," and "Stomach Neoplasms."</p><p><b>Study Selection</b>Original articles and reviews on the topics were selected.</p><p><b>Results</b>Anti-H. pylori antibody and serum PG concentration showed significant changes under the different status of H. pylori infection and the progression of atrophic gastritis, which can be used for risk stratification of gastric cancer in clinic. In addition, anti-H. pylori antibody titer can be used for further risk stratification of gastric cancer contributing to determine better endoscopy surveillance interval.</p><p><b>Conclusions</b>The early detection and diagnosis of gastric cancer benefit from the risk stratification, but the cutoff values for H. pylori antibody and serum PG concentration require further modification.</p>
Subject(s)
Humans , Antibodies, Bacterial , Blood , Allergy and Immunology , Gastroscopy , Helicobacter Infections , Blood , Allergy and Immunology , Helicobacter pylori , Allergy and Immunology , Mass Screening , Methods , Stomach Neoplasms , Blood , MicrobiologyABSTRACT
Respiratory syncytial virus (RSV),which is a major cause of lower respiratory tract infections during infancy and childhood,is also an important pathogen for immunosuppression in elder and diseased areas.In order to research the pathogenesis of RSV,the matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS)was used to explore the difference between uninfected cells and virus-infected cells.The result showed that,in the molecular weight range of 5000~10000 Da,there are three component peaks expressed with significant difference in both normal group and infection group.One of the three components was up-regulated (m/z 6154.25) and the other two were down-regulated (m/z 7658.47 and 9259.82) after RSV infection.This result proved the obvious differences between the infected cells and untreated cells.The differential expression may provide a feasible method for RSV disease diagnosis and pathology research,and also provide scientific evidences for research on development of RSV therapeutic drugs.
ABSTRACT
Rosai-Dorfman disease (RDD) is a rare histiocytic disorder that has nodal and extranodal manifestations. Currently no guidelines are available for the management of this disease. We report a case of laryngeal RDD that did not present with classical symptoms such as fever or lymphadenopathy and could be easily misdiagnosed as malignant tumor. The patient received minimally invasive surgeries combined with steroid therapy to preserve the laryngeal function as much as possible, and a favorable clinical outcome was obtained. Reports of similar cases in literatures were reviewed to obtain a better understanding of the disease course, diagnosis and treatment of this uncommon condition.
ABSTRACT
We explored the effect of therapy with bacteriophages for pandrug resistant Acinetobacter baumannii infections.Kunming mice (Specific Pathogen Free) were divided into two groups:experimental group (severe infection caused by pandrug resistant Acinetobacter baumannii) and the control group.The mice of experimental group were treated with Phages AB46 while the mice of control group were treated with broth.The survival rate was compared with statistical method and the spleen bacteria count was analyzed.Results showed that there were statistical difference between the experimental group and control group of Pandrug resistant Acinetobacter baumannii groups of 1 ∶ 10 dilution,P=0.020＜0.05.There were no statistical difference between each two groups of 1 ∶ 2 (P=0.650) and 1 ∶ 5 (P=0.170) dilution,both were＞0.05.There were no dead mice in groups of 1 ∶ 50 dilution with statistical difference of spleen bacteria count,P=0.026.Therapy with phages was an ef fective method to control infection caused by Pandrug resistant Acinetobacter baumannii which could increase the survival rate and decrease spleen bacteria count of the mice with light infection.